Life, death and drama at 20,000 feet, SKYMED weaves together intense character journeys and high-stakes medical rescues, as we follow the triumphs, heartbreaks and tribulations of budding nurses and pilots flying air ambulances in remote Northern Canada. They're all in over their heads, and on their own, with no one to rely on but each other.

桑福德（约翰·库萨克 John Cusack 饰）是一名精神病医生，在治愈他人疾病的同时，桑福德自己的家庭却伤痕累累。儿子本杰（伊万·伯德 Evan Bird 饰）年纪轻轻却因为吸毒而被关进了戒毒所，女儿阿加莎（米娅·华希科沃斯卡 Mia Wasikowska 饰）更糟，她竟然因为纵火而被关入了精神病院。